Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKCQ All Species: 36.67
Human Site: S676 Identified Species: 53.78
UniProt: Q04759 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04759 NP_006248.1 706 81865 S676 L N E K P R L S F A D R A L I
Chimpanzee Pan troglodytes XP_001147999 706 81847 S676 L N E K P R L S F A D R A L I
Rhesus Macaque Macaca mulatta XP_001083320 1140 127261 S1109 L N E K A R L S Y S D K N L I
Dog Lupus familis XP_849292 706 81555 S676 L N E K P R L S F A D R A L I
Cat Felis silvestris
Mouse Mus musculus Q02111 707 81555 S676 L S E K P R L S F A D R A L I
Rat Rattus norvegicus Q9WTQ0 707 81732 S676 L S E K P R L S F A D R A L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509836 708 81415 S678 L N E K P R L S F A D R A L I
Chicken Gallus gallus NP_001006133 699 80179 S668 L N E K P K L S Y S D K N L I
Frog Xenopus laevis Q7LZQ8 671 76506 T638 T R H P P V L T P P D H E V I
Zebra Danio Brachydanio rerio Q7SY24 670 76288 T638 T R H P P V L T P P D Q E V I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13678 634 71138 T602 T K E D P V L T P I G N E V V
Honey Bee Apis mellifera XP_394743 624 71014 F589 T K Y F D T A F T A E R P R L
Nematode Worm Caenorhab. elegans P34722 704 80280 N654 V P P P F K P N I K S N S D A
Sea Urchin Strong. purpuratus XP_787505 585 66691 A555 E F T M E K V A L S P T D T S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P24583 1151 131500 P1099 L N L R V K P P Y I P E I K S
Red Bread Mold Neurospora crassa P87253 1142 127954 P1092 Y H K R V Q P P F L P Q I K S
Conservation
Percent
Protein Identity: 100 99.7 33.6 96.7 N.A. 94.7 94 N.A. 86.1 63.3 33.9 34.1 N.A. 42.9 43.2 47.1 47.8
Protein Similarity: 100 99.7 45.1 98.3 N.A. 97.5 96.8 N.A. 92.9 77.1 48.2 49.2 N.A. 58.7 58.9 64.1 62
P-Site Identity: 100 100 66.6 100 N.A. 93.3 93.3 N.A. 100 66.6 26.6 26.6 N.A. 20 13.3 0 0
P-Site Similarity: 100 100 86.6 100 N.A. 100 100 N.A. 100 93.3 40 46.6 N.A. 40 26.6 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.2 26.5
Protein Similarity: N.A. N.A. N.A. N.A. 39.3 40.2
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 7 7 0 44 0 0 38 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 7 0 0 0 0 0 63 0 7 7 0 % D
% Glu: 7 0 57 0 7 0 0 0 0 0 7 7 19 0 0 % E
% Phe: 0 7 0 7 7 0 0 7 44 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % G
% His: 0 7 13 0 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 7 13 0 0 13 0 63 % I
% Lys: 0 13 7 50 0 25 0 0 0 7 0 13 0 13 0 % K
% Leu: 57 0 7 0 0 0 69 0 7 7 0 0 0 50 7 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 44 0 0 0 0 0 7 0 0 0 13 13 0 0 % N
% Pro: 0 7 7 19 63 0 19 13 19 13 19 0 7 0 0 % P
% Gln: 0 0 0 0 0 7 0 0 0 0 0 13 0 0 0 % Q
% Arg: 0 13 0 13 0 44 0 0 0 0 0 44 0 7 0 % R
% Ser: 0 13 0 0 0 0 0 50 0 19 7 0 7 0 19 % S
% Thr: 25 0 7 0 0 7 0 19 7 0 0 7 0 7 0 % T
% Val: 7 0 0 0 13 19 7 0 0 0 0 0 0 19 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 0 0 0 19 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _